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Technical Data


The Photoconductive Stimulation Device features.

Representation of the LED with stimulation properties depicted.

Feature List

  • Hippocampal/Cortical cultures are optimized for growth on silicon wafers

  • The photoconductive effect alters the conductivity of silicon with exposure to light

  • Illuminate as small an area as approximately 50 microns

  • Stimulation protocols can be from 0.1 Hz up to 100 Hz and approximately up to a 17 volt pulse across entire surface of wafer

  • Only illuminated neuron(s) depolarize on-demand

  • Activity can be detected by fluo4 or voltage sensitive dyes
  • Study cellular response by standard protocols or live imaging

  • Non-invasive, preserves cytoskeleton, physiologically benign

  • Cell specific (demonstrated by FM loading)

  • Concurrent electrophysiological recordings demonstrate high frequency stimulation possible

  • Stimulation can result in controlled synaptic and network remodeling

  • Networks formed have complex activity patterns

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